Guanylyl cyclase-activating protein 2 (GUCA1B)
Homo sapiens — UniProt Q9UMX6
Data last refreshed: (UniProt release unknown)
Key facts
Guanylyl cyclase-activating protein 2 (GUCA1B) is a protein from Homo sapiens identified by UniProt accession Q9UMX6, 200 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.
- UniProt accession: Q9UMX6; gene symbol GUCA1B.
- Organism: Homo sapiens.
- Length: 200 amino acids.
- Top disease associations (Open Targets): retinitis pigmentosa, autosomal dominant retinitis pigmentosa and eosinophil count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Guanylyl cyclase-activating protein 2 |
|---|---|
| UniProt accession | Q9UMX6 |
| Gene | GUCA1B |
| Organism | Homo sapiens |
| Length | 200 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (34)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa · score 0.58
- autosomal dominant retinitis pigmentosa · score 0.40
- eosinophil count · score 0.27
- Retinal dystrophy · score 0.13
- Leber congenital amaurosis · score 0.11
- eosinophil percentage of leukocytes · score 0.07
- neutrophil percentage of granulocytes · score 0.07
- eosinophil percentage of granulocytes · score 0.06
- C-reactive protein measurement · score 0.04
- non-small cell lung carcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UMX6-F1 | alphafold | PREDICTED | 71.30 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UMX6.
Amino-acid sequence (200 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GUCA1B?
The strongest Open Targets associations for GUCA1B are retinitis pigmentosa, autosomal dominant retinitis pigmentosa, eosinophil count, Retinal dystrophy and Leber congenital amaurosis.
How long is the GUCA1B protein?
The Homo sapiens GUCA1B protein (UniProt Q9UMX6) is 200 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UMX6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UMX6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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