U3 small nucleolar RNA-associated protein NOL7 (NOL7)
Homo sapiens — UniProt Q9UMY1
Data last refreshed: (UniProt release unknown)
Key facts
U3 small nucleolar RNA-associated protein NOL7 (NOL7) is a protein from Homo sapiens identified by UniProt accession Q9UMY1, 257 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.
- UniProt accession: Q9UMY1; gene symbol NOL7.
- Organism: Homo sapiens.
- Length: 257 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Alzheimer disease and lysosomal storage disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | U3 small nucleolar RNA-associated protein NOL7 |
|---|---|
| UniProt accession | Q9UMY1 |
| Gene | NOL7 |
| Organism | Homo sapiens |
| Length | 257 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (39)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.39
- Alzheimer disease · score 0.19
- lysosomal storage disease · score 0.19
- multiple sclerosis · score 0.19
- Parkinson disease · score 0.19
- lymphocyte count · score 0.06
- lymphocyte percentage of leukocytes · score 0.05
- neutrophil percentage of leukocytes · score 0.04
- aspartate aminotransferase measurement · score 0.04
- hematocrit · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UMY1-F1 | alphafold | PREDICTED | 71.01 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UMY1.
Amino-acid sequence (257 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NOL7?
The strongest Open Targets associations for NOL7 are neurodegenerative disease, Alzheimer disease, lysosomal storage disease, multiple sclerosis and Parkinson disease.
How long is the NOL7 protein?
The Homo sapiens NOL7 protein (UniProt Q9UMY1) is 257 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UMY1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UMY1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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