Sorting nexin-12 (SNX12)
Homo sapiens — UniProt Q9UMY4
Data last refreshed: (UniProt release unknown)
Key facts
Sorting nexin-12 (SNX12) is a protein from Homo sapiens identified by UniProt accession Q9UMY4, 162 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.
- UniProt accession: Q9UMY4; gene symbol SNX12.
- Organism: Homo sapiens.
- Length: 162 amino acids.
- Top disease associations (Open Targets): Romano-Ward syndrome, familial atrial fibrillation and Brugada syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sorting nexin-12 |
|---|---|
| UniProt accession | Q9UMY4 |
| Gene | SNX12 |
| Organism | Homo sapiens |
| Length | 162 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (49)
Diseases linked to this target (Open Targets).
- Romano-Ward syndrome · score 0.07
- familial atrial fibrillation · score 0.07
- Brugada syndrome · score 0.07
- Familial short QT syndrome · score 0.06
- Arrhythmogenic right ventricular dysplasia · score 0.06
- hypertrophic cardiomyopathy · score 0.05
- Brugada syndrome 9 · score 0.05
- Wolff-Parkinson-White Syndrome · score 0.05
- familial sick sinus syndrome · score 0.05
- Brugada syndrome 3 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UMY4-F1 | alphafold | PREDICTED | 90.65 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UMY4.
Amino-acid sequence (162 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SNX12?
The strongest Open Targets associations for SNX12 are Romano-Ward syndrome, familial atrial fibrillation, Brugada syndrome, Familial short QT syndrome and Arrhythmogenic right ventricular dysplasia.
How long is the SNX12 protein?
The Homo sapiens SNX12 protein (UniProt Q9UMY4) is 162 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UMY4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UMY4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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