A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5)
Homo sapiens — UniProt Q9UNA0
Data last refreshed: (UniProt release unknown)
Key facts
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) is a protein from Homo sapiens identified by UniProt accession Q9UNA0, 930 residues long. MolForge cross-references it against 0 known binders and 283 disease associations.
- UniProt accession: Q9UNA0; gene symbol ADAMTS5.
- Organism: Homo sapiens.
- Length: 930 amino acids.
- Top disease associations (Open Targets): body height, a disintegrin and metalloproteinase with thrombospondin motifs 5 measurement and BMI-adjusted waist circumference.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
|---|---|
| UniProt accession | Q9UNA0 |
| Gene | ADAMTS5 |
| Organism | Homo sapiens |
| Length | 930 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (283)
Diseases linked to this target (Open Targets).
- body height · score 0.48
- a disintegrin and metalloproteinase with thrombospondin motifs 5 measurement · score 0.40
- BMI-adjusted waist circumference · score 0.40
- FEV/FVC ratio · score 0.34
- blood protein measurement · score 0.33
- appendicular lean mass · score 0.32
- Hepatic failure · score 0.27
- breast adenocarcinoma · score 0.25
- heel bone mineral density · score 0.24
- bone density · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UNA0-F1 | alphafold | PREDICTED | 77.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UNA0.
Amino-acid sequence (930 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ADAMTS5?
The strongest Open Targets associations for ADAMTS5 are body height, a disintegrin and metalloproteinase with thrombospondin motifs 5 measurement, BMI-adjusted waist circumference, FEV/FVC ratio and blood protein measurement.
How long is the ADAMTS5 protein?
The Homo sapiens ADAMTS5 protein (UniProt Q9UNA0) is 930 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UNA0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UNA0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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