Rho GTPase-activating protein 26 (ARHGAP26)
Homo sapiens — UniProt Q9UNA1
Data last refreshed: (UniProt release unknown)
Key facts
Rho GTPase-activating protein 26 (ARHGAP26) is a protein from Homo sapiens identified by UniProt accession Q9UNA1, 814 residues long. MolForge cross-references it against 0 known binders and 289 disease associations.
- UniProt accession: Q9UNA1; gene symbol ARHGAP26.
- Organism: Homo sapiens.
- Length: 814 amino acids.
- Top disease associations (Open Targets): Juvenile Myelomonocytic Leukemia, eosinophil count and coronary artery disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rho GTPase-activating protein 26 |
|---|---|
| UniProt accession | Q9UNA1 |
| Gene | ARHGAP26 |
| Organism | Homo sapiens |
| Length | 814 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (289)
Diseases linked to this target (Open Targets).
- Juvenile Myelomonocytic Leukemia · score 0.47
- eosinophil count · score 0.44
- coronary artery disease · score 0.38
- pancreatic ductal adenocarcinoma · score 0.37
- pancreatic carcinoma · score 0.37
- gastric carcinoma · score 0.37
- prostate adenocarcinoma · score 0.37
- lymphoid neoplasm · score 0.37
- kidney neoplasm · score 0.37
- esophageal adenocarcinoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UNA1-F1 | alphafold | PREDICTED | 77.30 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UNA1.
Amino-acid sequence (814 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARHGAP26?
The strongest Open Targets associations for ARHGAP26 are Juvenile Myelomonocytic Leukemia, eosinophil count, coronary artery disease, pancreatic ductal adenocarcinoma and pancreatic carcinoma.
How long is the ARHGAP26 protein?
The Homo sapiens ARHGAP26 protein (UniProt Q9UNA1) is 814 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UNA1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UNA1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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