Alpha-1,4-N-acetylglucosaminyltransferase (A4GNT)
Homo sapiens — UniProt Q9UNA3
Data last refreshed: (UniProt release unknown)
Key facts
Alpha-1,4-N-acetylglucosaminyltransferase (A4GNT) is a protein from Homo sapiens identified by UniProt accession Q9UNA3, 340 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.
- UniProt accession: Q9UNA3; gene symbol A4GNT.
- Organism: Homo sapiens.
- Length: 340 amino acids.
- Top disease associations (Open Targets): genetic disorder, mathematical ability and attenuated familial adenomatous polyposis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Alpha-1,4-N-acetylglucosaminyltransferase |
|---|---|
| UniProt accession | Q9UNA3 |
| Gene | A4GNT |
| Organism | Homo sapiens |
| Length | 340 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (43)
Diseases linked to this target (Open Targets).
- genetic disorder · score 0.12
- mathematical ability · score 0.05
- attenuated familial adenomatous polyposis · score 0.05
- Barrett's esophagus · score 0.05
- hyperplastic polyposis syndrome · score 0.04
- pancreatic adenocarcinoma · score 0.04
- inflammatory bowel disease 30 · score 0.04
- CDH1-related diffuse gastric and lobular breast cancer syndrome · score 0.04
- Muir-Torre syndrome · score 0.04
- colorectal cancer · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UNA3-F1 | alphafold | PREDICTED | 88.73 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UNA3.
Amino-acid sequence (340 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with A4GNT?
The strongest Open Targets associations for A4GNT are genetic disorder, mathematical ability, attenuated familial adenomatous polyposis, Barrett's esophagus and hyperplastic polyposis syndrome.
How long is the A4GNT protein?
The Homo sapiens A4GNT protein (UniProt Q9UNA3) is 340 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UNA3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UNA3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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