DNA polymerase iota (POLI)
Homo sapiens — UniProt Q9UNA4
Data last refreshed: (UniProt release unknown)
Key facts
DNA polymerase iota (POLI) is a protein from Homo sapiens identified by UniProt accession Q9UNA4, 740 residues long. MolForge cross-references it against 1 known binders and 116 disease associations.
- UniProt accession: Q9UNA4; gene symbol POLI.
- Organism: Homo sapiens.
- Length: 740 amino acids.
- Top disease associations (Open Targets): asthma, allergic disease and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA polymerase iota |
|---|---|
| UniProt accession | Q9UNA4 |
| Gene | POLI |
| Organism | Homo sapiens |
| Length | 740 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (116)
Diseases linked to this target (Open Targets).
- asthma · score 0.30
- allergic disease · score 0.29
- neurodegenerative disease · score 0.29
- psoriasis · score 0.28
- erythrocyte count · score 0.27
- basophil count · score 0.27
- childhood onset asthma · score 0.26
- eosinophil percentage of leukocytes · score 0.26
- eosinophil count · score 0.25
- Eczematoid dermatitis · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UNA4-F1 | alphafold | PREDICTED | 70.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UNA4.
Amino-acid sequence (740 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with POLI?
The strongest Open Targets associations for POLI are asthma, allergic disease, neurodegenerative disease, psoriasis and erythrocyte count.
How long is the POLI protein?
The Homo sapiens POLI protein (UniProt Q9UNA4) is 740 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UNA4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UNA4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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