About Dual specificity protein phosphatase CDC14A
Dual specificity protein phosphatase CDC14A (CDC14A) is a protein
from Homo sapiens identified by UniProt accession
Q9UNH5, 594 residues long.
MolForge cross-references it against 0 known binders and
247 disease associations.
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
Disease associations (247)
Diseases linked to this target (Open Targets).
- hearing loss, autosomal recessive · score 0.63
- deafness · score 0.55
- creatinine measurement · score 0.42
- glucose measurement · score 0.39
- glomerular filtration rate · score 0.39
- hearing impairment and infertile male syndrome · score 0.37
- serum urea measurement · score 0.37
- HbA1c measurement · score 0.36
- neurodegenerative disease · score 0.36
- sensorineural hearing loss · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Experimental structures are not indexed in MolForge yet —
search RCSB PDB for Q9UNH5.
Amino-acid sequence (594 residues)
MAAESGELIG ACEFMKDRLY FATLRNRPKS TVNTHYFSID EELVYENFYA DFGPLNLAMV YRYCCKLNKK LKSYSLSRKK IVHYTCFDQR KRANAAFLIG AYAVIYLKKT PEEAYRALLS GSNPPYLPFR DASFGNCTYN LTILDCLQGI RKGLQHGFFD FETFDVDEYE HYERVENGDF NWIVPGKFLA FSGPHPKSKI ENGYPLHAPE AYFPYFKKHN VTAVVRLNKK IYEAKRFTDA GFEHYDLFFI DGSTPSDNIV RRFLNICENT EGAIAVHCKA GLGRTGTLIA CYVMKHYRFT HAEIIAWIRI CRPGSIIGPQ QHFLEEKQAS LWVQGDIFRS KLKNRPSSEG SINKILSGLD DMSIGGNLSK TQNMERFGED NLEDDDVEMK NGITQGDKLR ALKSQRQPRT SPSCAFRSDD TKGHPRAVSQ PFRLSSSLQG SAVTLKTSKM ALSPSATAKR INRTSLSSGA TVRSFSINSR LASSLGNLNA ATDDPENKKT SSSSKAGFTA SPFTNLLNGS SQPTTRNYPE LNNNQYNRSS NSNGGNLNSP PGPHSAKTEE HTTILRPSYT GLSSSSARFL SRSIPSLQSE YVHY
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