RNA 2',3'-cyclic phosphatase ANGEL1 (ANGEL1)
Homo sapiens — UniProt Q9UNK9
Data last refreshed: (UniProt release unknown)
Key facts
RNA 2',3'-cyclic phosphatase ANGEL1 (ANGEL1) is a protein from Homo sapiens identified by UniProt accession Q9UNK9, 670 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.
- UniProt accession: Q9UNK9; gene symbol ANGEL1.
- Organism: Homo sapiens.
- Length: 670 amino acids.
- Top disease associations (Open Targets): type 2 diabetes mellitus, urate measurement and bone density.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | RNA 2',3'-cyclic phosphatase ANGEL1 |
|---|---|
| UniProt accession | Q9UNK9 |
| Gene | ANGEL1 |
| Organism | Homo sapiens |
| Length | 670 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (23)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.20
- urate measurement · score 0.07
- bone density · score 0.07
- hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome · score 0.04
- thrombocytopenia, anemia, and myelofibrosis · score 0.04
- melorheostosis · score 0.04
- primary familial polycythemia due to EPO receptor mutation · score 0.04
- atrial fibrillation · score 0.04
- autosomal recessive hypophosphatemic rickets · score 0.04
- hemolytic anemia due to diphosphoglycerate mutase deficiency · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UNK9-F1 | alphafold | PREDICTED | 69.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UNK9.
Amino-acid sequence (670 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ANGEL1?
The strongest Open Targets associations for ANGEL1 are type 2 diabetes mellitus, urate measurement, bone density, hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome and thrombocytopenia, anemia, and myelofibrosis.
How long is the ANGEL1 protein?
The Homo sapiens ANGEL1 protein (UniProt Q9UNK9) is 670 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UNK9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UNK9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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