Endothelial protein C receptor (PROCR)

About Endothelial protein C receptor

Endothelial protein C receptor (PROCR) is a protein from Homo sapiens identified by UniProt accession Q9UNN8, 238 residues long. MolForge cross-references it against 0 known binders and 388 disease associations.

Target properties

Protein name	Endothelial protein C receptor
UniProt accession	Q9UNN8
Gene	PROCR
Organism	Homo sapiens
Length	238 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (388)

Diseases linked to this target (Open Targets).

protein C measurement · score 0.39
factor VII measurement · score 0.32
blood protein measurement · score 0.30
prothrombin time measurement · score 0.29
diastolic blood pressure · score 0.29
vitamin K-dependent protein C measurement · score 0.28
venous thromboembolism · score 0.28
coronary artery disease · score 0.27
breast adenocarcinoma · score 0.24
lung adenocarcinoma · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UNN8-F1	alphafold	PREDICTED	86.46	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UNN8.

Amino-acid sequence (238 residues)

MLTTLLPILL LSGWAFCSQD ASDGLQRLHM LQISYFRDPY HVWYQGNASL GGHLTHVLEG PDTNTTIIQL QPLQEPESWA RTQSGLQSYL LQFHGLVRLV HQERTLAFPL TIRCFLGCEL PPEGSRAHVF FEVAVNGSSF VSFRPERALW QADTQVTSGV VTFTLQQLNA YNRTRYELRE FLEDTCVQYV QKHISAENTK GSQTSRSYTS LVLGVLVGSF IIAGVAVGIF LCTGGRRC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards