ATP-sensitive inward rectifier potassium channel 14 (KCNJ14)

Homo sapiens — UniProt Q9UNX9

Gene: KCNJ14Homo sapiensSwissProt reviewed

About ATP-sensitive inward rectifier potassium channel 14

ATP-sensitive inward rectifier potassium channel 14 (KCNJ14) is a protein from Homo sapiens identified by UniProt accession Q9UNX9, 436 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.

Target properties

Protein nameATP-sensitive inward rectifier potassium channel 14
UniProt accessionQ9UNX9
GeneKCNJ14
OrganismHomo sapiens
Length436 residues
Molecular weight—
EC numbers—
Target class—
Subcellular location—
Keywords—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tierMEDIUM
Druggability score—
Pocket score—
Max clinical phase—

Disease associations (16)

Diseases linked to this target (Open Targets).

  • breast adenocarcinoma · score 0.22
  • thyroid gland adenocarcinoma · score 0.18
  • cutaneous melanoma · score 0.12
  • neoplasm · score 0.07
  • cancer · score 0.05
  • mean platelet volume · score 0.04
  • breast carcinoma · score 0.04
  • carcinoma of liver and intrahepatic biliary tract · score 0.02
  • lung adenocarcinoma · score 0.01
  • adrenal cortex carcinoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

StructureSourceMethodMean pLDDTResolution (Å)
AF-Q9UNX9-F1alphafoldPREDICTED80.07—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UNX9.

Amino-acid sequence (436 residues)

MGLARALRRL SGALDSGDSR AGDEEEAGPG LCRNGWAPAP VQSPVGRRRG RFVKKDGHCN VRFVNLGGQG ARYLSDLFTT CVDVRWRWMC LLFSCSFLAS WLLFGLAFWL IASLHGDLAA PPPPAPCFSH VASFLAAFLF ALETQTSIGY GVRSVTEECP AAVAAVVLQC IAGCVLDAFV VGAVMAKMAK PKKRNETLVF SENAVVALRD HRLCLMWRVG NLRRSHLVEA HVRAQLLQPR VTPEGEYIPL DHQDVDVGFD GGTDRIFLVS PITIVHEIDS ASPLYELGRA ELARADFELV VILEGMVEAT AMTTQCRSSY LPGELLWGHR FEPVLFQRGS QYEVDYRHFH RTYEVPGTPV CSAKELDERA EQASHSLKSS FPGSLTAFCY ENELALSCCQ EEDEDDETEE GNGVETEDGA ASPRVLTPTL ALTLPP

Explore ATP-sensitive inward rectifier potassium channel 14 with MolForge

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Quick facts

UniProtQ9UNX9
GeneKCNJ14
OrganismHomo sapiens
Length436
Binders0
Diseases16
View on UniProt