SRSF protein kinase 3 (SRPK3)
Homo sapiens — UniProt Q9UPE1
Data last refreshed: (UniProt release unknown)
Key facts
SRSF protein kinase 3 (SRPK3) is a protein from Homo sapiens identified by UniProt accession Q9UPE1, 567 residues long. MolForge cross-references it against 11 known binders and 117 disease associations.
- UniProt accession: Q9UPE1; gene symbol SRPK3.
- Organism: Homo sapiens.
- Length: 567 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Neurodevelopmental disorder and multiminicore myopathy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SRSF protein kinase 3 |
|---|---|
| UniProt accession | Q9UPE1 |
| Gene | SRPK3 |
| Organism | Homo sapiens |
| Length | 567 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (117)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- Neurodevelopmental disorder · score 0.12
- multiminicore myopathy · score 0.12
- exercise intolerance, riboflavin-responsive · score 0.08
- Distal myopathy, Nonaka type · score 0.07
- spinal muscular atrophy, facioscapulohumeral type · score 0.07
- myopathy · score 0.07
- inclusion body myopathy with Paget disease of bone and frontotemporal dementia · score 0.07
- inclusion body myositis · score 0.07
- tibial muscular dystrophy · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UPE1-F1 | alphafold | PREDICTED | 78.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UPE1.
Amino-acid sequence (567 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SRPK3?
The strongest Open Targets associations for SRPK3 are neurodegenerative disease, Neurodevelopmental disorder, multiminicore myopathy, exercise intolerance, riboflavin-responsive and Distal myopathy, Nonaka type.
How long is the SRPK3 protein?
The Homo sapiens SRPK3 protein (UniProt Q9UPE1) is 567 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UPE1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UPE1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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