Zinc finger protein PLAGL2 (PLAGL2)
Homo sapiens — UniProt Q9UPG8
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger protein PLAGL2 (PLAGL2) is a protein from Homo sapiens identified by UniProt accession Q9UPG8, 496 residues long. MolForge cross-references it against 0 known binders and 108 disease associations.
- UniProt accession: Q9UPG8; gene symbol PLAGL2.
- Organism: Homo sapiens.
- Length: 496 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, inflammatory bowel disease and hepatocellular carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger protein PLAGL2 |
|---|---|
| UniProt accession | Q9UPG8 |
| Gene | PLAGL2 |
| Organism | Homo sapiens |
| Length | 496 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (108)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- inflammatory bowel disease · score 0.14
- hepatocellular carcinoma · score 0.11
- neoplasm · score 0.10
- age at first sexual intercourse measurement · score 0.09
- blood protein measurement · score 0.09
- gonorrhea · score 0.08
- neuroblastoma · score 0.08
- glioblastoma multiforme · score 0.08
- smoking cessation · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UPG8-F1 | alphafold | PREDICTED | 54.05 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UPG8.
Amino-acid sequence (496 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLAGL2?
The strongest Open Targets associations for PLAGL2 are neurodegenerative disease, inflammatory bowel disease, hepatocellular carcinoma, neoplasm and age at first sexual intercourse measurement.
How long is the PLAGL2 protein?
The Homo sapiens PLAGL2 protein (UniProt Q9UPG8) is 496 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UPG8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UPG8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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