Ubiquitin carboxyl-terminal hydrolase 22 (USP22)
Homo sapiens — UniProt Q9UPT9
Data last refreshed: (UniProt release unknown)
Key facts
Ubiquitin carboxyl-terminal hydrolase 22 (USP22) is a protein from Homo sapiens identified by UniProt accession Q9UPT9, 525 residues long. MolForge cross-references it against 0 known binders and 176 disease associations.
- UniProt accession: Q9UPT9; gene symbol USP22.
- Organism: Homo sapiens.
- Length: 525 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, protein measurement and pancreatic adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubiquitin carboxyl-terminal hydrolase 22 |
|---|---|
| UniProt accession | Q9UPT9 |
| Gene | USP22 |
| Organism | Homo sapiens |
| Length | 525 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (176)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- protein measurement · score 0.32
- pancreatic adenocarcinoma · score 0.26
- breast adenocarcinoma · score 0.26
- glioblastoma multiforme · score 0.24
- ovarian cancer · score 0.23
- lysosomal storage disease · score 0.18
- hepatocellular carcinoma · score 0.12
- neoplasm · score 0.11
- cancer · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UPT9-F1 | alphafold | PREDICTED | 83.12 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UPT9.
Amino-acid sequence (525 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with USP22?
The strongest Open Targets associations for USP22 are neurodegenerative disease, protein measurement, pancreatic adenocarcinoma, breast adenocarcinoma and glioblastoma multiforme.
How long is the USP22 protein?
The Homo sapiens USP22 protein (UniProt Q9UPT9) is 525 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UPT9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UPT9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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