VPS10 domain-containing receptor SorCS3 (SORCS3)
Homo sapiens — UniProt Q9UPU3
Data last refreshed: (UniProt release unknown)
Key facts
VPS10 domain-containing receptor SorCS3 (SORCS3) is a protein from Homo sapiens identified by UniProt accession Q9UPU3, 1222 residues long. MolForge cross-references it against 0 known binders and 95 disease associations.
- UniProt accession: Q9UPU3; gene symbol SORCS3.
- Organism: Homo sapiens.
- Length: 1222 amino acids.
- Top disease associations (Open Targets): unipolar depression, mathematical ability and attention deficit hyperactivity disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | VPS10 domain-containing receptor SorCS3 |
|---|---|
| UniProt accession | Q9UPU3 |
| Gene | SORCS3 |
| Organism | Homo sapiens |
| Length | 1222 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (95)
Diseases linked to this target (Open Targets).
- unipolar depression · score 0.52
- mathematical ability · score 0.51
- attention deficit hyperactivity disorder · score 0.51
- self reported educational attainment · score 0.50
- schizophrenia · score 0.49
- smoking status measurement · score 0.48
- wellbeing measurement · score 0.48
- autism spectrum disorder · score 0.48
- age at first sexual intercourse measurement · score 0.47
- bipolar disorder · score 0.47
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UPU3-F1 | alphafold | PREDICTED | 74.69 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UPU3.
Amino-acid sequence (1222 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SORCS3?
The strongest Open Targets associations for SORCS3 are unipolar depression, mathematical ability, attention deficit hyperactivity disorder, self reported educational attainment and schizophrenia.
How long is the SORCS3 protein?
The Homo sapiens SORCS3 protein (UniProt Q9UPU3) is 1222 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UPU3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UPU3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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