TBC1 domain family member 2B (TBC1D2B)
Homo sapiens — UniProt Q9UPU7
Data last refreshed: (UniProt release unknown)
Key facts
TBC1 domain family member 2B (TBC1D2B) is a protein from Homo sapiens identified by UniProt accession Q9UPU7, 963 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.
- UniProt accession: Q9UPU7; gene symbol TBC1D2B.
- Organism: Homo sapiens.
- Length: 963 amino acids.
- Top disease associations (Open Targets): serum albumin measurement, Neurodevelopmental disorder and intellectual disability-obesity-prognathism-eye and skin anomalies syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | TBC1 domain family member 2B |
|---|---|
| UniProt accession | Q9UPU7 |
| Gene | TBC1D2B |
| Organism | Homo sapiens |
| Length | 963 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (59)
Diseases linked to this target (Open Targets).
- serum albumin measurement · score 0.49
- Neurodevelopmental disorder · score 0.37
- intellectual disability-obesity-prognathism-eye and skin anomalies syndrome · score 0.37
- total blood protein measurement · score 0.32
- neurodegenerative disease · score 0.32
- calcium measurement · score 0.30
- hematocrit · score 0.20
- genetic disorder · score 0.19
- erythrocyte count · score 0.08
- mean corpuscular hemoglobin concentration · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UPU7-F1 | alphafold | PREDICTED | 70.38 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UPU7.
Amino-acid sequence (963 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TBC1D2B?
The strongest Open Targets associations for TBC1D2B are serum albumin measurement, Neurodevelopmental disorder, intellectual disability-obesity-prognathism-eye and skin anomalies syndrome, total blood protein measurement and neurodegenerative disease.
How long is the TBC1D2B protein?
The Homo sapiens TBC1D2B protein (UniProt Q9UPU7) is 963 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UPU7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UPU7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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