Voltage-gated delayed rectifier potassium channel KCNH4 (KCNH4)
Homo sapiens — UniProt Q9UQ05
Data last refreshed: (UniProt release unknown)
Key facts
Voltage-gated delayed rectifier potassium channel KCNH4 (KCNH4) is a protein from Homo sapiens identified by UniProt accession Q9UQ05, 1017 residues long. MolForge cross-references it against 0 known binders and 73 disease associations.
- UniProt accession: Q9UQ05; gene symbol KCNH4.
- Organism: Homo sapiens.
- Length: 1017 amino acids.
- Top disease associations (Open Targets): multiple sclerosis, Myasthenia gravis and small cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Voltage-gated delayed rectifier potassium channel KCNH4 |
|---|---|
| UniProt accession | Q9UQ05 |
| Gene | KCNH4 |
| Organism | Homo sapiens |
| Length | 1017 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (73)
Diseases linked to this target (Open Targets).
- multiple sclerosis · score 0.59
- Myasthenia gravis · score 0.57
- small cell carcinoma · score 0.46
- Muscle weakness · score 0.46
- secondary progressive multiple sclerosis · score 0.43
- primary progressive multiple sclerosis · score 0.37
- transverse myelitis · score 0.37
- anterior ischemic optic neuropathy · score 0.37
- atrial flutter · score 0.35
- atrial fibrillation · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UQ05-F1 | alphafold | PREDICTED | 66.74 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UQ05.
Amino-acid sequence (1017 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KCNH4?
The strongest Open Targets associations for KCNH4 are multiple sclerosis, Myasthenia gravis, small cell carcinoma, Muscle weakness and secondary progressive multiple sclerosis.
How long is the KCNH4 protein?
The Homo sapiens KCNH4 protein (UniProt Q9UQ05) is 1017 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UQ05 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UQ05 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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