MAPK/MAK/MRK overlapping kinase (MOK)

About MAPK/MAK/MRK overlapping kinase

MAPK/MAK/MRK overlapping kinase (MOK) is a protein from Homo sapiens identified by UniProt accession Q9UQ07, 419 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.

Target properties

Protein name	MAPK/MAK/MRK overlapping kinase
UniProt accession	Q9UQ07
Gene	MOK
Organism	Homo sapiens
Length	419 residues
Molecular weight	—
EC numbers	—
Target class	Kinase (inferred from UniProt keywords / EC)
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (58)

Diseases linked to this target (Open Targets).

Red cell distribution width · score 0.45
urate measurement · score 0.44
body mass index · score 0.35
mean corpuscular hemoglobin concentration · score 0.32
neuroinflammatory disorder · score 0.32
uric acid measurement · score 0.30
mean corpuscular hemoglobin · score 0.29
glomerular filtration rate · score 0.16
mucopolysaccharidosis type 3 · score 0.12
mean corpuscular volume · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UQ07-F1	alphafold	PREDICTED	76.19	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UQ07.

Amino-acid sequence (419 residues)

MKNYKAIGKI GEGTFSEVMK MQSLRDGNYY ACKQMKQRFE SIEQVNNLRE IQALRRLNPH PNILMLHEVV FDRKSGSLAL ICELMDMNIY ELIRGRRYPL SEKKIMHYMY QLCKSLDHIH RNGIFHRDVK PENILIKQDV LKLGDFGSCR SVYSKQPYTE YISTRWYRAP ECLLTDGFYT YKMDLWSAGC VFYEIASLQP LFPGVNELDQ ISKIHDVIGT PAQKILTKFK QSRAMNFDFP FKKGSGIPLL TTNLSPQCLS LLHAMVAYDP DERIAAHQAL QHPYFQEQRK TEKRALGSHR KAGFPEHPVA PEPLSNSCQI SKEGRKQKQS LKQEEDRPKR RGPAYVMELP KLKLSGVVRL SSYSSPTLQS VLGSGTNGRV PVLRPLKCIP ASKKTDPQKD LKPAPQQCRL PTIVRKGGR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards