Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (DHDH)
Homo sapiens — UniProt Q9UQ10
Data last refreshed: (UniProt release unknown)
Key facts
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (DHDH) is a protein from Homo sapiens identified by UniProt accession Q9UQ10, 334 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.
- UniProt accession: Q9UQ10; gene symbol DHDH.
- Organism: Homo sapiens.
- Length: 334 amino acids.
- Top disease associations (Open Targets): prostate carcinoma, prostate cancer and Familial prostate cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase |
|---|---|
| UniProt accession | Q9UQ10 |
| Gene | DHDH |
| Organism | Homo sapiens |
| Length | 334 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (37)
Diseases linked to this target (Open Targets).
- prostate carcinoma · score 0.11
- prostate cancer · score 0.11
- Familial prostate cancer · score 0.11
- Crohn's disease · score 0.04
- leukocyte count · score 0.03
- eosinophil percentage of leukocytes · score 0.03
- drug use measurement · score 0.03
- platelet count · score 0.02
- vital capacity · score 0.02
- eosinophil percentage of granulocytes · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UQ10-F1 | alphafold | PREDICTED | 98.27 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UQ10.
Amino-acid sequence (334 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DHDH?
The strongest Open Targets associations for DHDH are prostate carcinoma, prostate cancer, Familial prostate cancer, Crohn's disease and leukocyte count.
How long is the DHDH protein?
The Homo sapiens DHDH protein (UniProt Q9UQ10) is 334 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UQ10 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UQ10 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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