Leucine-rich repeat protein SHOC-2 (SHOC2)
Homo sapiens — UniProt Q9UQ13
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat protein SHOC-2 (SHOC2) is a protein from Homo sapiens identified by UniProt accession Q9UQ13, 582 residues long. MolForge cross-references it against 0 known binders and 106 disease associations.
- UniProt accession: Q9UQ13; gene symbol SHOC2.
- Organism: Homo sapiens.
- Length: 582 amino acids.
- Top disease associations (Open Targets): Noonan syndrome-like disorder with loose anagen hair, Noonan syndrome and rasopathy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat protein SHOC-2 |
|---|---|
| UniProt accession | Q9UQ13 |
| Gene | SHOC2 |
| Organism | Homo sapiens |
| Length | 582 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (106)
Diseases linked to this target (Open Targets).
- Noonan syndrome-like disorder with loose anagen hair · score 0.70
- Noonan syndrome · score 0.62
- rasopathy · score 0.51
- neurodegenerative disease · score 0.46
- Noonan syndrome and Noonan-related syndrome · score 0.41
- esophageal carcinoma · score 0.37
- Abnormality of the cardiovascular system · score 0.34
- Pectus excavatum · score 0.34
- autosomal recessive polycystic kidney disease · score 0.34
- genetic disorder · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UQ13-F1 | alphafold | PREDICTED | 87.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UQ13.
Amino-acid sequence (582 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SHOC2?
The strongest Open Targets associations for SHOC2 are Noonan syndrome-like disorder with loose anagen hair, Noonan syndrome, rasopathy, neurodegenerative disease and Noonan syndrome and Noonan-related syndrome.
How long is the SHOC2 protein?
The Homo sapiens SHOC2 protein (UniProt Q9UQ13) is 582 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UQ13 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UQ13 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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