Regulating synaptic membrane exocytosis protein 2 (RIMS2)
Homo sapiens — UniProt Q9UQ26
Data last refreshed: (UniProt release unknown)
Key facts
Regulating synaptic membrane exocytosis protein 2 (RIMS2) is a protein from Homo sapiens identified by UniProt accession Q9UQ26, 1411 residues long. MolForge cross-references it against 0 known binders and 117 disease associations.
- UniProt accession: Q9UQ26; gene symbol RIMS2.
- Organism: Homo sapiens.
- Length: 1411 amino acids.
- Top disease associations (Open Targets): cone-rod synaptic disorder syndrome, congenital nonprogressive, self reported educational attainment and intelligence.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Regulating synaptic membrane exocytosis protein 2 |
|---|---|
| UniProt accession | Q9UQ26 |
| Gene | RIMS2 |
| Organism | Homo sapiens |
| Length | 1411 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (117)
Diseases linked to this target (Open Targets).
- cone-rod synaptic disorder syndrome, congenital nonprogressive · score 0.62
- self reported educational attainment · score 0.27
- intelligence · score 0.24
- particulate matter air pollution measurement · score 0.13
- MODY · score 0.06
- GCGR-related hyperglucagonemia · score 0.06
- hyperinsulinism-hyperammonemia syndrome · score 0.05
- hyperinsulinism due to INSR deficiency · score 0.05
- hyperinsulinism due to glucokinase deficiency · score 0.05
- exercise-induced hyperinsulinism · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UQ26-F1 | alphafold | PREDICTED | 54.51 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UQ26.
Amino-acid sequence (1411 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RIMS2?
The strongest Open Targets associations for RIMS2 are cone-rod synaptic disorder syndrome, congenital nonprogressive, self reported educational attainment, intelligence, particulate matter air pollution measurement and MODY.
How long is the RIMS2 protein?
The Homo sapiens RIMS2 protein (UniProt Q9UQ26) is 1411 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UQ26 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UQ26 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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