Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B (MGAT4B)
Homo sapiens — UniProt Q9UQ53
Data last refreshed: (UniProt release unknown)
Key facts
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B (MGAT4B) is a protein from Homo sapiens identified by UniProt accession Q9UQ53, 548 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.
- UniProt accession: Q9UQ53; gene symbol MGAT4B.
- Organism: Homo sapiens.
- Length: 548 amino acids.
- Top disease associations (Open Targets): COVID-19, mean platelet volume and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B |
|---|---|
| UniProt accession | Q9UQ53 |
| Gene | MGAT4B |
| Organism | Homo sapiens |
| Length | 548 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (85)
Diseases linked to this target (Open Targets).
- COVID-19 · score 0.37
- mean platelet volume · score 0.35
- neurodegenerative disease · score 0.34
- monocyte count · score 0.26
- blood protein measurement · score 0.25
- platelet count · score 0.23
- platelet crit · score 0.15
- Red cell distribution width · score 0.10
- lymphocyte:monocyte ratio · score 0.08
- lymphocyte count · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UQ53-F1 | alphafold | PREDICTED | 83.75 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UQ53.
Amino-acid sequence (548 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MGAT4B?
The strongest Open Targets associations for MGAT4B are COVID-19, mean platelet volume, neurodegenerative disease, monocyte count and blood protein measurement.
How long is the MGAT4B protein?
The Homo sapiens MGAT4B protein (UniProt Q9UQ53) is 548 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UQ53 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UQ53 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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