Pregnancy-specific beta-1-glycoprotein 8 (PSG8)
Homo sapiens — UniProt Q9UQ74
Data last refreshed: (UniProt release unknown)
Key facts
Pregnancy-specific beta-1-glycoprotein 8 (PSG8) is a protein from Homo sapiens identified by UniProt accession Q9UQ74, 426 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: Q9UQ74; gene symbol PSG8.
- Organism: Homo sapiens.
- Length: 426 amino acids.
- Top disease associations (Open Targets): glioblastoma multiforme, breast adenocarcinoma and venous thromboembolism.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pregnancy-specific beta-1-glycoprotein 8 |
|---|---|
| UniProt accession | Q9UQ74 |
| Gene | PSG8 |
| Organism | Homo sapiens |
| Length | 426 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.18
- venous thromboembolism · score 0.16
- thyroid gland adenocarcinoma · score 0.16
- head and neck squamous cell carcinoma · score 0.11
- low grade glioma · score 0.10
- birth weight · score 0.08
- obesity due to melanocortin 4 receptor deficiency · score 0.06
- blood protein measurement · score 0.05
- LIPE-related familial partial lipodystrophy · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UQ74-F1 | alphafold | PREDICTED | 87.30 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UQ74.
Amino-acid sequence (426 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PSG8?
The strongest Open Targets associations for PSG8 are glioblastoma multiforme, breast adenocarcinoma, venous thromboembolism, thyroid gland adenocarcinoma and head and neck squamous cell carcinoma.
How long is the PSG8 protein?
The Homo sapiens PSG8 protein (UniProt Q9UQ74) is 426 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UQ74 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UQ74 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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