Proliferation-associated protein 2G4 (PA2G4)
Homo sapiens — UniProt Q9UQ80
Data last refreshed: (UniProt release unknown)
Key facts
Proliferation-associated protein 2G4 (PA2G4) is a protein from Homo sapiens identified by UniProt accession Q9UQ80, 394 residues long. MolForge cross-references it against 0 known binders and 111 disease associations.
- UniProt accession: Q9UQ80; gene symbol PA2G4.
- Organism: Homo sapiens.
- Length: 394 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, body mass index and body weight.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Proliferation-associated protein 2G4 |
|---|---|
| UniProt accession | Q9UQ80 |
| Gene | PA2G4 |
| Organism | Homo sapiens |
| Length | 394 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (111)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- body mass index · score 0.17
- body weight · score 0.15
- fat body mass · score 0.14
- acute myeloid leukemia · score 0.12
- lean body mass · score 0.11
- body fat percentage · score 0.10
- hepatocellular carcinoma · score 0.09
- Blackfan-Diamond anemia · score 0.08
- serum alanine aminotransferase measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UQ80-F1 | alphafold | PREDICTED | 92.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UQ80.
Amino-acid sequence (394 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PA2G4?
The strongest Open Targets associations for PA2G4 are neurodegenerative disease, body mass index, body weight, fat body mass and acute myeloid leukemia.
How long is the PA2G4 protein?
The Homo sapiens PA2G4 protein (UniProt Q9UQ80) is 394 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UQ80 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UQ80 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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