Exonuclease 1 (EXO1)
Homo sapiens — UniProt Q9UQ84
Data last refreshed: (UniProt release unknown)
Key facts
Exonuclease 1 (EXO1) is a protein from Homo sapiens identified by UniProt accession Q9UQ84, 846 residues long. MolForge cross-references it against 0 known binders and 280 disease associations.
- UniProt accession: Q9UQ84; gene symbol EXO1.
- Organism: Homo sapiens.
- Length: 846 amino acids.
- Top disease associations (Open Targets): cancer, eosinophil count and mean corpuscular volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Exonuclease 1 |
|---|---|
| UniProt accession | Q9UQ84 |
| Gene | EXO1 |
| Organism | Homo sapiens |
| Length | 846 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (280)
Diseases linked to this target (Open Targets).
- cancer · score 0.62
- eosinophil count · score 0.47
- mean corpuscular volume · score 0.46
- mean corpuscular hemoglobin · score 0.44
- mean corpuscular hemoglobin concentration · score 0.43
- age at menopause · score 0.41
- breast carcinoma · score 0.40
- eosinophil percentage of leukocytes · score 0.39
- neurodegenerative disease · score 0.36
- breast cancer · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UQ84-F1 | alphafold | PREDICTED | 63.45 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UQ84.
Amino-acid sequence (846 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EXO1?
The strongest Open Targets associations for EXO1 are cancer, eosinophil count, mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration.
How long is the EXO1 protein?
The Homo sapiens EXO1 protein (UniProt Q9UQ84) is 846 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UQ84 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UQ84 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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