Mitochondrial inner membrane m-AAA protease component paraplegin (SPG7)
Homo sapiens — UniProt Q9UQ90
Data last refreshed: (UniProt release unknown)
Key facts
Mitochondrial inner membrane m-AAA protease component paraplegin (SPG7) is a protein from Homo sapiens identified by UniProt accession Q9UQ90, 795 residues long. MolForge cross-references it against 0 known binders and 200 disease associations.
- UniProt accession: Q9UQ90; gene symbol SPG7.
- Organism: Homo sapiens.
- Length: 795 amino acids.
- Top disease associations (Open Targets): Autosomal recessive spastic paraplegia type 7, hereditary spastic paraplegia 7 and hereditary spastic paraplegia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitochondrial inner membrane m-AAA protease component paraplegin |
|---|---|
| UniProt accession | Q9UQ90 |
| Gene | SPG7 |
| Organism | Homo sapiens |
| Length | 795 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (200)
Diseases linked to this target (Open Targets).
- Autosomal recessive spastic paraplegia type 7 · score 0.83
- hereditary spastic paraplegia 7 · score 0.83
- hereditary spastic paraplegia · score 0.58
- genetic disorder · score 0.52
- spastic ataxia · score 0.50
- Gait ataxia · score 0.46
- Spastic paraparesis · score 0.43
- Cerebral cortical atrophy · score 0.43
- Dysarthria · score 0.43
- Spastic paraplegia · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UQ90-F1 | alphafold | PREDICTED | 73.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UQ90.
Amino-acid sequence (795 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPG7?
The strongest Open Targets associations for SPG7 are Autosomal recessive spastic paraplegia type 7, hereditary spastic paraplegia 7, hereditary spastic paraplegia, genetic disorder and spastic ataxia.
How long is the SPG7 protein?
The Homo sapiens SPG7 protein (UniProt Q9UQ90) is 795 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UQ90 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UQ90 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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