BAR/IMD domain-containing adapter protein 2 (BAIAP2)

About BAR/IMD domain-containing adapter protein 2

BAR/IMD domain-containing adapter protein 2 (BAIAP2) is a protein from Homo sapiens identified by UniProt accession Q9UQB8, 552 residues long. MolForge cross-references it against 0 known binders and 143 disease associations.

Target properties

Protein name	BAR/IMD domain-containing adapter protein 2
UniProt accession	Q9UQB8
Gene	BAIAP2
Organism	Homo sapiens
Length	552 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (143)

Diseases linked to this target (Open Targets).

neuroticism measurement · score 0.44
body weight · score 0.43
body mass index · score 0.42
lean body mass · score 0.41
body height · score 0.40
mathematical ability · score 0.37
body fat percentage · score 0.37
depressive symptom measurement · score 0.37
wellbeing measurement · score 0.37
attention deficit hyperactivity disorder · score 0.35

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UQB8-F1	alphafold	PREDICTED	71.68	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UQB8.

Amino-acid sequence (552 residues)

MSLSRSEEMH RLTENVYKTI MEQFNPSLRN FIAMGKNYEK ALAGVTYAAK GYFDALVKMG ELASESQGSK ELGDVLFQMA EVHRQIQNQL EEMLKSFHNE LLTQLEQKVE LDSRYLSAAL KKYQTEQRSK GDALDKCQAE LKKLRKKSQG SKNPQKYSDK ELQYIDAISN KQGELENYVS DGYKTALTEE RRRFCFLVEK QCAVAKNSAA YHSKGKELLA QKLPLWQQAC ADPSKIPERA VQLMQQVASN GATLPSALSA SKSNLVISDP IPGAKPLPVP PELAPFVGRM SAQESTPIMN GVTGPDGEDY SPWADRKAAQ PKSLSPPQSQ SKLSDSYSNT LPVRKSVTPK NSYATTENKT LPRSSSMAAG LERNGRMRVK AIFSHAAGDN STLLSFKEGD LITLLVPEAR DGWHYGESEK TKMRGWFPFS YTRVLDSDGS DRLHMSLQQG KSSSTGNLLD KDDLAIPPPD YGAASRAFPA QTASGFKQRP YSVAVPAFSQ GLDDYGARSM SRNPFAHVQL KPTVTNDRCD LSAQGPEGRE HGDGSARTLA GR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards