Aurora kinase C (AURKC)
Homo sapiens — UniProt Q9UQB9
Data last refreshed: (UniProt release unknown)
Key facts
Aurora kinase C (AURKC) is a protein from Homo sapiens identified by UniProt accession Q9UQB9, 309 residues long. MolForge cross-references it against 14 known binders and 122 disease associations.
- UniProt accession: Q9UQB9; gene symbol AURKC.
- Organism: Homo sapiens.
- Length: 309 amino acids.
- Top disease associations (Open Targets): spermatogenic failure 5, Male infertility due to large-headed multiflagellar polyploid spermatozoa and Male infertility with spermatogenesis disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Aurora kinase C |
|---|---|
| UniProt accession | Q9UQB9 |
| Gene | AURKC |
| Organism | Homo sapiens |
| Length | 309 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (122)
Diseases linked to this target (Open Targets).
- spermatogenic failure 5 · score 0.62
- Male infertility due to large-headed multiflagellar polyploid spermatozoa · score 0.46
- Male infertility with spermatogenesis disorder · score 0.34
- neurodegenerative disease · score 0.25
- genetic disorder · score 0.19
- azoospermia · score 0.14
- cancer · score 0.10
- leukemia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- neoplasm · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UQB9-F1 | alphafold | PREDICTED | 84.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UQB9.
Amino-acid sequence (309 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AURKC?
The strongest Open Targets associations for AURKC are spermatogenic failure 5, Male infertility due to large-headed multiflagellar polyploid spermatozoa, Male infertility with spermatogenesis disorder, neurodegenerative disease and genetic disorder.
How long is the AURKC protein?
The Homo sapiens AURKC protein (UniProt Q9UQB9) is 309 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UQB9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UQB9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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