GRB2-associated-binding protein 2 (GAB2)
Homo sapiens — UniProt Q9UQC2
Data last refreshed: (UniProt release unknown)
Key facts
GRB2-associated-binding protein 2 (GAB2) is a protein from Homo sapiens identified by UniProt accession Q9UQC2, 676 residues long. MolForge cross-references it against 0 known binders and 307 disease associations.
- UniProt accession: Q9UQC2; gene symbol GAB2.
- Organism: Homo sapiens.
- Length: 676 amino acids.
- Top disease associations (Open Targets): cancer, chronic myelogenous leukemia and hair color.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | GRB2-associated-binding protein 2 |
|---|---|
| UniProt accession | Q9UQC2 |
| Gene | GAB2 |
| Organism | Homo sapiens |
| Length | 676 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (307)
Diseases linked to this target (Open Targets).
- cancer · score 0.61
- chronic myelogenous leukemia · score 0.54
- hair color · score 0.44
- glomerular filtration rate · score 0.43
- triglyceride measurement · score 0.42
- FEV/FVC ratio · score 0.41
- hair colour measurement · score 0.41
- aspartate aminotransferase measurement · score 0.41
- age at menarche · score 0.41
- diastolic blood pressure · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UQC2-F1 | alphafold | PREDICTED | 51.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UQC2.
Amino-acid sequence (676 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GAB2?
The strongest Open Targets associations for GAB2 are cancer, chronic myelogenous leukemia, hair color, glomerular filtration rate and triglyceride measurement.
How long is the GAB2 protein?
The Homo sapiens GAB2 protein (UniProt Q9UQC2) is 676 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UQC2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UQC2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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