Sodium channel protein type 8 subunit alpha (SCN8A)
Homo sapiens — UniProt Q9UQD0
Data last refreshed: (UniProt release unknown)
Key facts
Sodium channel protein type 8 subunit alpha (SCN8A) is a protein from Homo sapiens identified by UniProt accession Q9UQD0, 1980 residues long. MolForge cross-references it against 7 known binders and 1,179 disease associations.
- UniProt accession: Q9UQD0; gene symbol SCN8A.
- Organism: Homo sapiens.
- Length: 1980 amino acids.
- Approved drugs acting on it (DrugCentral): Cannabidiol, Benzocaine, Lamotrigine, Mepivacaine and Phenytoin and others.
- Top disease associations (Open Targets): developmental and epileptic encephalopathy, 13, seizures, benign familial infantile, 5 and Seizure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sodium channel protein type 8 subunit alpha |
|---|---|
| UniProt accession | Q9UQD0 |
| Gene | SCN8A |
| Organism | Homo sapiens |
| Length | 1980 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (6)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (1179)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy, 13 · score 0.84
- seizures, benign familial infantile, 5 · score 0.77
- Seizure · score 0.73
- cognitive impairment with or without cerebellar ataxia · score 0.73
- epilepsy · score 0.71
- partial epilepsy · score 0.66
- pain · score 0.61
- bipolar disorder · score 0.61
- atrial fibrillation · score 0.60
- migraine disorder · score 0.60
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UQD0-F1 | alphafold | PREDICTED | 68.35 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UQD0.
Amino-acid sequence (1980 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target SCN8A?
DrugCentral lists 6 approved drugs whose mechanism of action is SCN8A: Cannabidiol, Benzocaine, Lamotrigine, Mepivacaine, Phenytoin and Ropivacaine.
Which diseases are associated with SCN8A?
The strongest Open Targets associations for SCN8A are developmental and epileptic encephalopathy, 13, seizures, benign familial infantile, 5, Seizure, cognitive impairment with or without cerebellar ataxia and epilepsy.
How long is the SCN8A protein?
The Homo sapiens SCN8A protein (UniProt Q9UQD0) is 1980 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UQD0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UQD0 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.