Structural maintenance of chromosomes protein 3 (SMC3)
Homo sapiens — UniProt Q9UQE7
Data last refreshed: (UniProt release unknown)
Key facts
Structural maintenance of chromosomes protein 3 (SMC3) is a protein from Homo sapiens identified by UniProt accession Q9UQE7, 1217 residues long. MolForge cross-references it against 0 known binders and 123 disease associations.
- UniProt accession: Q9UQE7; gene symbol SMC3.
- Organism: Homo sapiens.
- Length: 1217 amino acids.
- Top disease associations (Open Targets): Cornelia de Lange syndrome, genetic disorder and Wiedemann-Steiner syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Structural maintenance of chromosomes protein 3 |
|---|---|
| UniProt accession | Q9UQE7 |
| Gene | SMC3 |
| Organism | Homo sapiens |
| Length | 1217 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (123)
Diseases linked to this target (Open Targets).
- Cornelia de Lange syndrome · score 0.76
- genetic disorder · score 0.47
- Wiedemann-Steiner syndrome · score 0.33
- Intellectual disability · score 0.30
- neurodegenerative disease · score 0.30
- autism spectrum disorder · score 0.26
- breast adenocarcinoma · score 0.26
- endometrial cancer · score 0.25
- ovarian cancer · score 0.23
- head and neck squamous cell carcinoma · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UQE7-F1 | alphafold | PREDICTED | 82.08 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UQE7.
Amino-acid sequence (1217 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMC3?
The strongest Open Targets associations for SMC3 are Cornelia de Lange syndrome, genetic disorder, Wiedemann-Steiner syndrome, Intellectual disability and neurodegenerative disease.
How long is the SMC3 protein?
The Homo sapiens SMC3 protein (UniProt Q9UQE7) is 1217 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UQE7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UQE7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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