Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A)
Homo sapiens — UniProt Q9UQM7
Data last refreshed: (UniProt release unknown)
Key facts
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) is a protein from Homo sapiens identified by UniProt accession Q9UQM7, 478 residues long. MolForge cross-references it against 10 known binders and 200 disease associations.
- UniProt accession: Q9UQM7; gene symbol CAMK2A.
- Organism: Homo sapiens.
- Length: 478 amino acids.
- Top disease associations (Open Targets): intellectual disability, autosomal dominant 53, Intellectual disability and autosomal recessive non-syndromic intellectual disability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Calcium/calmodulin-dependent protein kinase type II subunit alpha |
|---|---|
| UniProt accession | Q9UQM7 |
| Gene | CAMK2A |
| Organism | Homo sapiens |
| Length | 478 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (200)
Diseases linked to this target (Open Targets).
- intellectual disability, autosomal dominant 53 · score 0.77
- Intellectual disability · score 0.66
- autosomal recessive non-syndromic intellectual disability · score 0.44
- autosomal dominant non-syndromic intellectual disability · score 0.37
- gut microbiome measurement · score 0.36
- neurodegenerative disease · score 0.33
- glioblastoma multiforme · score 0.31
- thyroid gland adenocarcinoma · score 0.30
- breast adenocarcinoma · score 0.29
- Global developmental delay · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UQM7-F1 | alphafold | PREDICTED | 85.79 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UQM7.
Amino-acid sequence (478 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CAMK2A?
The strongest Open Targets associations for CAMK2A are intellectual disability, autosomal dominant 53, Intellectual disability, autosomal recessive non-syndromic intellectual disability, autosomal dominant non-syndromic intellectual disability and gut microbiome measurement.
How long is the CAMK2A protein?
The Homo sapiens CAMK2A protein (UniProt Q9UQM7) is 478 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UQM7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UQM7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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