Charged multivesicular body protein 2b (CHMP2B)
Homo sapiens — UniProt Q9UQN3
Data last refreshed: (UniProt release unknown)
Key facts
Charged multivesicular body protein 2b (CHMP2B) is a protein from Homo sapiens identified by UniProt accession Q9UQN3, 213 residues long. MolForge cross-references it against 0 known binders and 210 disease associations.
- UniProt accession: Q9UQN3; gene symbol CHMP2B.
- Organism: Homo sapiens.
- Length: 213 amino acids.
- Top disease associations (Open Targets): amyotrophic lateral sclerosis, frontotemporal dementia and behavioral variant of frontotemporal dementia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Charged multivesicular body protein 2b |
|---|---|
| UniProt accession | Q9UQN3 |
| Gene | CHMP2B |
| Organism | Homo sapiens |
| Length | 213 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (210)
Diseases linked to this target (Open Targets).
- amyotrophic lateral sclerosis · score 0.69
- frontotemporal dementia · score 0.66
- behavioral variant of frontotemporal dementia · score 0.63
- viral disease · score 0.46
- HIV infection · score 0.46
- Dystonia · score 0.46
- prostate carcinoma · score 0.42
- Frontotemporal dementia · score 0.37
- Amyotrophic lateral sclerosis · score 0.37
- severe acute respiratory syndrome · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UQN3-F1 | alphafold | PREDICTED | 79.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UQN3.
Amino-acid sequence (213 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CHMP2B?
The strongest Open Targets associations for CHMP2B are amyotrophic lateral sclerosis, frontotemporal dementia, behavioral variant of frontotemporal dementia, viral disease and HIV infection.
How long is the CHMP2B protein?
The Homo sapiens CHMP2B protein (UniProt Q9UQN3) is 213 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UQN3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UQN3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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