SH2B adapter protein 3 (SH2B3)
Homo sapiens — UniProt Q9UQQ2
Data last refreshed: (UniProt release unknown)
Key facts
SH2B adapter protein 3 (SH2B3) is a protein from Homo sapiens identified by UniProt accession Q9UQQ2, 575 residues long. MolForge cross-references it against 0 known binders and 691 disease associations.
- UniProt accession: Q9UQQ2; gene symbol SH2B3.
- Organism: Homo sapiens.
- Length: 575 amino acids.
- Top disease associations (Open Targets): platelet count, platelet crit and cystatin C measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SH2B adapter protein 3 |
|---|---|
| UniProt accession | Q9UQQ2 |
| Gene | SH2B3 |
| Organism | Homo sapiens |
| Length | 575 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (691)
Diseases linked to this target (Open Targets).
- platelet count · score 0.69
- platelet crit · score 0.68
- cystatin C measurement · score 0.62
- leukocyte count · score 0.62
- reticulocyte count · score 0.61
- eosinophil count · score 0.59
- lymphocyte count · score 0.57
- neutrophil count · score 0.57
- reticulocyte measurement · score 0.57
- high density lipoprotein cholesterol measurement · score 0.55
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UQQ2-F1 | alphafold | PREDICTED | 62.13 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UQQ2.
Amino-acid sequence (575 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SH2B3?
The strongest Open Targets associations for SH2B3 are platelet count, platelet crit, cystatin C measurement, leukocyte count and reticulocyte count.
How long is the SH2B3 protein?
The Homo sapiens SH2B3 protein (UniProt Q9UQQ2) is 575 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UQQ2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UQQ2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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