Sex comb on midleg-like protein 2 (SCML2)
Homo sapiens — UniProt Q9UQR0
Data last refreshed: (UniProt release unknown)
Key facts
Sex comb on midleg-like protein 2 (SCML2) is a protein from Homo sapiens identified by UniProt accession Q9UQR0, 700 residues long. MolForge cross-references it against 0 known binders and 110 disease associations.
- UniProt accession: Q9UQR0; gene symbol SCML2.
- Organism: Homo sapiens.
- Length: 700 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, azoospermia and partial chromosome Y deletion.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sex comb on midleg-like protein 2 |
|---|---|
| UniProt accession | Q9UQR0 |
| Gene | SCML2 |
| Organism | Homo sapiens |
| Length | 700 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (110)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- azoospermia · score 0.10
- partial chromosome Y deletion · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- spermatogenic failure, X-linked, 2 · score 0.08
- spermatogenic failures 50 · score 0.08
- spermatogenic failure 25 · score 0.08
- spermatogenic failure 61 · score 0.08
- spermatogenic failure 59 · score 0.08
- spermatogenic failure 73 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UQR0-F1 | alphafold | PREDICTED | 68.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UQR0.
Amino-acid sequence (700 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SCML2?
The strongest Open Targets associations for SCML2 are neurodegenerative disease, azoospermia, partial chromosome Y deletion, male infertility with teratozoospermia due to single gene mutation and spermatogenic failure, X-linked, 2.
How long is the SCML2 protein?
The Homo sapiens SCML2 protein (UniProt Q9UQR0) is 700 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UQR0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UQR0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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