Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 (MTMR6)
Homo sapiens — UniProt Q9Y217
Data last refreshed: (UniProt release unknown)
Key facts
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 (MTMR6) is a protein from Homo sapiens identified by UniProt accession Q9Y217, 621 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.
- UniProt accession: Q9Y217; gene symbol MTMR6.
- Organism: Homo sapiens.
- Length: 621 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Alzheimer disease and Parkinson disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 |
|---|---|
| UniProt accession | Q9Y217 |
| Gene | MTMR6 |
| Organism | Homo sapiens |
| Length | 621 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (23)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- Alzheimer disease · score 0.50
- Parkinson disease · score 0.50
- lysosomal storage disease · score 0.50
- multiple sclerosis · score 0.50
- breast adenocarcinoma · score 0.25
- triglyceride measurement · score 0.25
- head and neck squamous cell carcinoma · score 0.19
- melanoma · score 0.16
- neuroinflammatory disorder · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y217-F1 | alphafold | PREDICTED | 87.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y217.
Amino-acid sequence (621 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MTMR6?
The strongest Open Targets associations for MTMR6 are neurodegenerative disease, Alzheimer disease, Parkinson disease, lysosomal storage disease and multiple sclerosis.
How long is the MTMR6 protein?
The Homo sapiens MTMR6 protein (UniProt Q9Y217) is 621 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y217 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y217 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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