60S ribosome subunit biogenesis protein NIP7 homolog (NIP7)
Homo sapiens — UniProt Q9Y221
Data last refreshed: (UniProt release unknown)
Key facts
60S ribosome subunit biogenesis protein NIP7 homolog (NIP7) is a protein from Homo sapiens identified by UniProt accession Q9Y221, 180 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.
- UniProt accession: Q9Y221; gene symbol NIP7.
- Organism: Homo sapiens.
- Length: 180 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, congenital disorder of glycosylation and COG8-congenital disorder of glycosylation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 60S ribosome subunit biogenesis protein NIP7 homolog |
|---|---|
| UniProt accession | Q9Y221 |
| Gene | NIP7 |
| Organism | Homo sapiens |
| Length | 180 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (19)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.47
- congenital disorder of glycosylation · score 0.12
- COG8-congenital disorder of glycosylation · score 0.12
- triglyceride measurement · score 0.06
- handedness · score 0.05
- sitting height measurement · score 0.05
- telomere length · score 0.04
- daytime rest measurement · score 0.04
- alcohol consumption measurement · score 0.03
- high density lipoprotein cholesterol measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y221-F1 | alphafold | PREDICTED | 93.91 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y221.
Amino-acid sequence (180 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NIP7?
The strongest Open Targets associations for NIP7 are neurodegenerative disease, congenital disorder of glycosylation, COG8-congenital disorder of glycosylation, triglyceride measurement and handedness.
How long is the NIP7 protein?
The Homo sapiens NIP7 protein (UniProt Q9Y221) is 180 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y221 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y221 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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