Type 2 lactosamine alpha-2,3-sialyltransferase (ST3GAL6)
Homo sapiens — UniProt Q9Y274
Data last refreshed: (UniProt release unknown)
Key facts
Type 2 lactosamine alpha-2,3-sialyltransferase (ST3GAL6) is a protein from Homo sapiens identified by UniProt accession Q9Y274, 331 residues long. MolForge cross-references it against 0 known binders and 114 disease associations.
- UniProt accession: Q9Y274; gene symbol ST3GAL6.
- Organism: Homo sapiens.
- Length: 331 amino acids.
- Top disease associations (Open Targets): blood protein measurement, eosinophil count and vascular endothelial growth factor receptor 3 measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Type 2 lactosamine alpha-2,3-sialyltransferase |
|---|---|
| UniProt accession | Q9Y274 |
| Gene | ST3GAL6 |
| Organism | Homo sapiens |
| Length | 331 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (114)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.45
- eosinophil count · score 0.40
- vascular endothelial growth factor receptor 3 measurement · score 0.39
- neutrophil count · score 0.39
- leukocyte count · score 0.39
- eosinophil percentage of leukocytes · score 0.36
- monocyte count · score 0.36
- alkaline phosphatase measurement · score 0.36
- myeloid white cell count · score 0.31
- IGF-1 measurement · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y274-F1 | alphafold | PREDICTED | 91.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y274.
Amino-acid sequence (331 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ST3GAL6?
The strongest Open Targets associations for ST3GAL6 are blood protein measurement, eosinophil count, vascular endothelial growth factor receptor 3 measurement, neutrophil count and leukocyte count.
How long is the ST3GAL6 protein?
The Homo sapiens ST3GAL6 protein (UniProt Q9Y274) is 331 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y274 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y274 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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