Inversin (INVS)
Homo sapiens — UniProt Q9Y283
Data last refreshed: (UniProt release unknown)
Key facts
Inversin (INVS) is a protein from Homo sapiens identified by UniProt accession Q9Y283, 1065 residues long. MolForge cross-references it against 0 known binders and 175 disease associations.
- UniProt accession: Q9Y283; gene symbol INVS.
- Organism: Homo sapiens.
- Length: 1065 amino acids.
- Top disease associations (Open Targets): nephronophthisis 2, nephronophthisis and Infantile nephronophthisis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Inversin |
|---|---|
| UniProt accession | Q9Y283 |
| Gene | INVS |
| Organism | Homo sapiens |
| Length | 1065 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (175)
Diseases linked to this target (Open Targets).
- nephronophthisis 2 · score 0.70
- nephronophthisis · score 0.68
- Infantile nephronophthisis · score 0.66
- Senior-Loken syndrome · score 0.56
- Nephronophthisis · score 0.47
- genetic disorder · score 0.41
- macula measurement · score 0.28
- erythrocyte count · score 0.27
- retinal layer thickness measurement · score 0.26
- ganglion cell inner plexiform layer thickness measurement · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y283-F1 | alphafold | PREDICTED | 70.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y283.
Amino-acid sequence (1065 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with INVS?
The strongest Open Targets associations for INVS are nephronophthisis 2, nephronophthisis, Infantile nephronophthisis, Senior-Loken syndrome and Nephronophthisis.
How long is the INVS protein?
The Homo sapiens INVS protein (UniProt Q9Y283) is 1065 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y283 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y283 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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