F-box/WD repeat-containing protein 1A (BTRC)
Homo sapiens — UniProt Q9Y297
Data last refreshed: (UniProt release unknown)
Key facts
F-box/WD repeat-containing protein 1A (BTRC) is a protein from Homo sapiens identified by UniProt accession Q9Y297, 605 residues long. MolForge cross-references it against 0 known binders and 236 disease associations.
- UniProt accession: Q9Y297; gene symbol BTRC.
- Organism: Homo sapiens.
- Length: 605 amino acids.
- Top disease associations (Open Targets): HIV infection, smoking status measurement and Red cell distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | F-box/WD repeat-containing protein 1A |
|---|---|
| UniProt accession | Q9Y297 |
| Gene | BTRC |
| Organism | Homo sapiens |
| Length | 605 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (236)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.53
- smoking status measurement · score 0.40
- Red cell distribution width · score 0.39
- ulcerative colitis · score 0.37
- smoking initiation · score 0.31
- smoking behavior · score 0.31
- Vertigo · score 0.30
- vestibular disease · score 0.30
- gait measurement · score 0.29
- body mass index · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y297-F1 | alphafold | PREDICTED | 79.71 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y297.
Amino-acid sequence (605 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BTRC?
The strongest Open Targets associations for BTRC are HIV infection, smoking status measurement, Red cell distribution width, ulcerative colitis and smoking initiation.
How long is the BTRC protein?
The Homo sapiens BTRC protein (UniProt Q9Y297) is 605 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y297 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y297 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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