About F-box/WD repeat-containing protein 1A
F-box/WD repeat-containing protein 1A (BTRC) is a protein
from Homo sapiens identified by UniProt accession
Q9Y297, 605 residues long.
MolForge cross-references it against 0 known binders and
236 disease associations.
Target properties
| Protein name | F-box/WD repeat-containing protein 1A |
|---|
| UniProt accession | Q9Y297 |
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| Gene | BTRC |
|---|
| Organism | Homo sapiens |
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| Length | 605 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (236)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.53
- smoking status measurement · score 0.40
- Red cell distribution width · score 0.39
- ulcerative colitis · score 0.37
- smoking initiation · score 0.31
- smoking behavior · score 0.31
- Vertigo · score 0.30
- vestibular disease · score 0.30
- gait measurement · score 0.29
- body mass index · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y297-F1 | alphafold | PREDICTED | 79.71 | — |
Amino-acid sequence (605 residues)
MDPAEAVLQE KALKFMCSMP RSLWLGCSSL ADSMPSLRCL YNPGTGALTA FQNSSEREDC NNGEPPRKII PEKNSLRQTY NSCARLCLNQ ETVCLASTAM KTENCVAKTK LANGTSSMIV PKQRKLSASY EKEKELCVKY FEQWSESDQV EFVEHLISQM CHYQHGHINS YLKPMLQRDF ITALPARGLD HIAENILSYL DAKSLCAAEL VCKEWYRVTS DGMLWKKLIE RMVRTDSLWR GLAERRGWGQ YLFKNKPPDG NAPPNSFYRA LYPKIIQDIE TIESNWRCGR HSLQRIHCRS ETSKGVYCLQ YDDQKIVSGL RDNTIKIWDK NTLECKRILT GHTGSVLCLQ YDERVIITGS SDSTVRVWDV NTGEMLNTLI HHCEAVLHLR FNNGMMVTCS KDRSIAVWDM ASPTDITLRR VLVGHRAAVN VVDFDDKYIV SASGDRTIKV WNTSTCEFVR TLNGHKRGIA CLQYRDRLVV SGSSDNTIRL WDIECGACLR VLEGHEELVR CIRFDNKRIV SGAYDGKIKV WDLVAALDPR APAGTLCLRT LVEHSGRVFR LQFDEFQIVS SSHDDTILIW DFLNDPAAQA EPPRSPSRTY TYISR
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