Zinc finger protein 443 (ZNF443)
Homo sapiens — UniProt Q9Y2A4
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger protein 443 (ZNF443) is a protein from Homo sapiens identified by UniProt accession Q9Y2A4, 671 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.
- UniProt accession: Q9Y2A4; gene symbol ZNF443.
- Organism: Homo sapiens.
- Length: 671 amino acids.
- Top disease associations (Open Targets): diastolic blood pressure, hypertension and hemoglobin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger protein 443 |
|---|---|
| UniProt accession | Q9Y2A4 |
| Gene | ZNF443 |
| Organism | Homo sapiens |
| Length | 671 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (13)
Diseases linked to this target (Open Targets).
- diastolic blood pressure · score 0.28
- hypertension · score 0.21
- hemoglobin measurement · score 0.20
- erythrocyte count · score 0.18
- cognitive function measurement · score 0.12
- mathematical ability · score 0.12
- self reported educational attainment · score 0.05
- intelligence · score 0.02
- insulin resistance · score 0.01
- Down syndrome · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2A4-F1 | alphafold | PREDICTED | 72.91 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2A4.
Amino-acid sequence (671 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZNF443?
The strongest Open Targets associations for ZNF443 are diastolic blood pressure, hypertension, hemoglobin measurement, erythrocyte count and cognitive function measurement.
How long is the ZNF443 protein?
The Homo sapiens ZNF443 protein (UniProt Q9Y2A4) is 671 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2A4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2A4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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