Nck-associated protein 1 (NCKAP1)
Homo sapiens — UniProt Q9Y2A7
Data last refreshed: (UniProt release unknown)
Key facts
Nck-associated protein 1 (NCKAP1) is a protein from Homo sapiens identified by UniProt accession Q9Y2A7, 1128 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.
- UniProt accession: Q9Y2A7; gene symbol NCKAP1.
- Organism: Homo sapiens.
- Length: 1128 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Intellectual disability and Autistic behavior.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nck-associated protein 1 |
|---|---|
| UniProt accession | Q9Y2A7 |
| Gene | NCKAP1 |
| Organism | Homo sapiens |
| Length | 1128 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (69)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- Intellectual disability · score 0.44
- Autistic behavior · score 0.43
- complex neurodevelopmental disorder · score 0.40
- Autism · score 0.37
- autism · score 0.37
- Neurodevelopmental abnormality · score 0.34
- genetic disorder · score 0.34
- Global developmental delay · score 0.33
- blood protein measurement · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2A7-F1 | alphafold | PREDICTED | 92.60 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2A7.
Amino-acid sequence (1128 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NCKAP1?
The strongest Open Targets associations for NCKAP1 are neurodegenerative disease, Intellectual disability, Autistic behavior, complex neurodevelopmental disorder and Autism.
How long is the NCKAP1 protein?
The Homo sapiens NCKAP1 protein (UniProt Q9Y2A7) is 1128 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2A7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2A7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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