Ribitol-5-phosphate xylosyltransferase 1 (RXYLT1)
Homo sapiens — UniProt Q9Y2B1
Data last refreshed: (UniProt release unknown)
Key facts
Ribitol-5-phosphate xylosyltransferase 1 (RXYLT1) is a protein from Homo sapiens identified by UniProt accession Q9Y2B1, 443 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.
- UniProt accession: Q9Y2B1; gene symbol RXYLT1.
- Organism: Homo sapiens.
- Length: 443 amino acids.
- Top disease associations (Open Targets): muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10, muscular dystrophy-dystroglycanopathy, type A and muscle-eye-brain disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ribitol-5-phosphate xylosyltransferase 1 |
|---|---|
| UniProt accession | Q9Y2B1 |
| Gene | RXYLT1 |
| Organism | Homo sapiens |
| Length | 443 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (43)
Diseases linked to this target (Open Targets).
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10 · score 0.73
- muscular dystrophy-dystroglycanopathy, type A · score 0.50
- muscle-eye-brain disease · score 0.37
- genetic disorder · score 0.19
- Griscelli syndrome type 3 · score 0.05
- attention deficit hyperactivity disorder · score 0.04
- uncombable hair syndrome · score 0.04
- Griscelli disease · score 0.04
- Griscelli disease type 3 · score 0.04
- oculocutaneous albinism type 3 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2B1-F1 | alphafold | PREDICTED | 85.51 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2B1.
Amino-acid sequence (443 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RXYLT1?
The strongest Open Targets associations for RXYLT1 are muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10, muscular dystrophy-dystroglycanopathy, type A, muscle-eye-brain disease, genetic disorder and Griscelli syndrome type 3.
How long is the RXYLT1 protein?
The Homo sapiens RXYLT1 protein (UniProt Q9Y2B1) is 443 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2B1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2B1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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