cAMP-dependent protein kinase inhibitor gamma (PKIG)
Homo sapiens — UniProt Q9Y2B9
Data last refreshed: (UniProt release unknown)
Key facts
cAMP-dependent protein kinase inhibitor gamma (PKIG) is a protein from Homo sapiens identified by UniProt accession Q9Y2B9, 76 residues long. MolForge cross-references it against 0 known binders and 77 disease associations.
- UniProt accession: Q9Y2B9; gene symbol PKIG.
- Organism: Homo sapiens.
- Length: 76 amino acids.
- Top disease associations (Open Targets): Severe combined immunodeficiency due to adenosine deaminase deficiency, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency and severe combined immunodeficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | cAMP-dependent protein kinase inhibitor gamma |
|---|---|
| UniProt accession | Q9Y2B9 |
| Gene | PKIG |
| Organism | Homo sapiens |
| Length | 76 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (77)
Diseases linked to this target (Open Targets).
- Severe combined immunodeficiency due to adenosine deaminase deficiency · score 0.58
- severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency · score 0.58
- severe combined immunodeficiency · score 0.49
- partial adenosine deaminase deficiency · score 0.49
- severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive · score 0.34
- neurodegenerative disease · score 0.30
- psoriasis · score 0.28
- emotional symptom measurement · score 0.22
- heart failure · score 0.18
- coronary artery disease · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2B9-F1 | alphafold | PREDICTED | 62.87 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2B9.
Amino-acid sequence (76 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PKIG?
The strongest Open Targets associations for PKIG are Severe combined immunodeficiency due to adenosine deaminase deficiency, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency, severe combined immunodeficiency, partial adenosine deaminase deficiency and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive.
How long is the PKIG protein?
The Homo sapiens PKIG protein (UniProt Q9Y2B9) is 76 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2B9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2B9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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