Cyclic AMP-dependent transcription factor ATF-5 (ATF5)
Homo sapiens — UniProt Q9Y2D1
Data last refreshed: (UniProt release unknown)
Key facts
Cyclic AMP-dependent transcription factor ATF-5 (ATF5) is a protein from Homo sapiens identified by UniProt accession Q9Y2D1, 282 residues long. MolForge cross-references it against 0 known binders and 127 disease associations.
- UniProt accession: Q9Y2D1; gene symbol ATF5.
- Organism: Homo sapiens.
- Length: 282 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, neuroinflammatory disorder and lysosomal storage disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cyclic AMP-dependent transcription factor ATF-5 |
|---|---|
| UniProt accession | Q9Y2D1 |
| Gene | ATF5 |
| Organism | Homo sapiens |
| Length | 282 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (127)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- neuroinflammatory disorder · score 0.37
- lysosomal storage disease · score 0.37
- multiple sclerosis · score 0.37
- Alzheimer disease · score 0.37
- Parkinson disease · score 0.37
- age at menopause · score 0.15
- neoplasm · score 0.11
- cancer · score 0.09
- glioblastoma multiforme · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2D1-F1 | alphafold | PREDICTED | 67.55 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2D1.
Amino-acid sequence (282 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ATF5?
The strongest Open Targets associations for ATF5 are neurodegenerative disease, neuroinflammatory disorder, lysosomal storage disease, multiple sclerosis and Alzheimer disease.
How long is the ATF5 protein?
The Homo sapiens ATF5 protein (UniProt Q9Y2D1) is 282 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2D1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2D1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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