About Afadin- and alpha-actinin-binding protein
Afadin- and alpha-actinin-binding protein (SSX2IP) is a protein
from Homo sapiens identified by UniProt accession
Q9Y2D8, 614 residues long.
MolForge cross-references it against 0 known binders and
51 disease associations.
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
Disease associations (51)
Diseases linked to this target (Open Targets).
- Parkinson disease · score 0.23
- lysosomal storage disease · score 0.23
- multiple sclerosis · score 0.23
- Alzheimer disease · score 0.23
- neurodegenerative disease · score 0.23
- mean platelet volume · score 0.22
- autism spectrum disorder symptom · score 0.16
- hepatocellular carcinoma · score 0.08
- acute lymphoblastic leukemia · score 0.08
- cancer · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Experimental structures are not indexed in MolForge yet —
search RCSB PDB for Q9Y2D8.
Amino-acid sequence (614 residues)
MGDWMTVTDP GLSSESKTIS QYTSETKMSP SSLYSQQVLC SSIPLSKNVH SFFSAFCTED NIEQSISYLD QELTTFGFPS LYEESKGKET KRELNIVAVL NCMNELLVLQ RKNLLAQENV ETQNLKLGSD MDHLQSCYSK LKEQLETSRR EMIGLQERDR QLQCKNRNLH QLLKNEKDEV QKLQNIIASR ATQYNHDMKR KEREYNKLKE RLHQLVMNKK DKKIAMDILN YVGRADGKRG SWRTGKTEAR NEDEMYKILL NDYEYRQKQI LMENAELKKV LQQMKKEMIS LLSPQKKKPR ERVDDSTGTV ISDVEEDAGE LSRESMWDLS CETVREQLTN SIRKQWRILK SHVEKLDNQV SKVHLEGFND EDVISRQDHE QETEKLELEI QQCKEMIKTQ QQLLQQQLAT AYDDDTTSLL RDCYLLEEKE RLKEEWSLFK EQKKNFERER RSFTEAAIRL GLERKAFEEE RASWLKQQFL NMTTFDHQNS ENVKLFSAFS GSSDWDNLIV HSRQPQKKPH SVSNGSPVCM SKLTKSLPAS PSTSDFCQTR SCISEHSSIN VLNITAEEIK PNQVGGECTN QKWSVASRPG SQEGCYSGCS LSYTNSHVEK DDLP
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