Epididymis-specific alpha-mannosidase (MAN2B2)
Homo sapiens — UniProt Q9Y2E5
Data last refreshed: (UniProt release unknown)
Key facts
Epididymis-specific alpha-mannosidase (MAN2B2) is a protein from Homo sapiens identified by UniProt accession Q9Y2E5, 1009 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.
- UniProt accession: Q9Y2E5; gene symbol MAN2B2.
- Organism: Homo sapiens.
- Length: 1009 amino acids.
- Top disease associations (Open Targets): blood protein measurement, congenital disorder of glycosylation and primary intestinal lymphangiectasia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Epididymis-specific alpha-mannosidase |
|---|---|
| UniProt accession | Q9Y2E5 |
| Gene | MAN2B2 |
| Organism | Homo sapiens |
| Length | 1009 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (29)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.36
- congenital disorder of glycosylation · score 0.26
- primary intestinal lymphangiectasia · score 0.03
- Omenn syndrome · score 0.03
- Chronic mucocutaneous candidosis · score 0.03
- aplasia cutis congenita-intestinal lymphangiectasia syndrome · score 0.03
- Aplasia cutis congenita - intestinal lymphangiectasia · score 0.03
- type 2 diabetes mellitus · score 0.02
- Drugs used in diabetes use measurement · score 0.02
- gut microbiome measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2E5-F1 | alphafold | PREDICTED | 91.04 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2E5.
Amino-acid sequence (1009 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MAN2B2?
The strongest Open Targets associations for MAN2B2 are blood protein measurement, congenital disorder of glycosylation, primary intestinal lymphangiectasia, Omenn syndrome and Chronic mucocutaneous candidosis.
How long is the MAN2B2 protein?
The Homo sapiens MAN2B2 protein (UniProt Q9Y2E5) is 1009 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2E5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2E5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.