E3 ubiquitin-protein ligase DTX4 (DTX4)
Homo sapiens — UniProt Q9Y2E6
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase DTX4 (DTX4) is a protein from Homo sapiens identified by UniProt accession Q9Y2E6, 619 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.
- UniProt accession: Q9Y2E6; gene symbol DTX4.
- Organism: Homo sapiens.
- Length: 619 amino acids.
- Top disease associations (Open Targets): brain volume measurement, endometrial cancer and lung adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase DTX4 |
|---|---|
| UniProt accession | Q9Y2E6 |
| Gene | DTX4 |
| Organism | Homo sapiens |
| Length | 619 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (41)
Diseases linked to this target (Open Targets).
- brain volume measurement · score 0.27
- endometrial cancer · score 0.23
- lung adenocarcinoma · score 0.23
- head and neck squamous cell carcinoma · score 0.21
- cutaneous melanoma · score 0.18
- breast adenocarcinoma · score 0.18
- glioblastoma multiforme · score 0.11
- heel bone mineral density · score 0.03
- body height · score 0.03
- papillary thyroid carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2E6-F1 | alphafold | PREDICTED | 75.55 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2E6.
Amino-acid sequence (619 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DTX4?
The strongest Open Targets associations for DTX4 are brain volume measurement, endometrial cancer, lung adenocarcinoma, head and neck squamous cell carcinoma and cutaneous melanoma.
How long is the DTX4 protein?
The Homo sapiens DTX4 protein (UniProt Q9Y2E6) is 619 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2E6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2E6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.