Sodium/hydrogen exchanger 8 (SLC9A8)
Homo sapiens — UniProt Q9Y2E8
Data last refreshed: (UniProt release unknown)
Key facts
Sodium/hydrogen exchanger 8 (SLC9A8) is a protein from Homo sapiens identified by UniProt accession Q9Y2E8, 581 residues long. MolForge cross-references it against 0 known binders and 214 disease associations.
- UniProt accession: Q9Y2E8; gene symbol SLC9A8.
- Organism: Homo sapiens.
- Length: 581 amino acids.
- Top disease associations (Open Targets): psoriasis, ulcerative colitis and Crohn's disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sodium/hydrogen exchanger 8 |
|---|---|
| UniProt accession | Q9Y2E8 |
| Gene | SLC9A8 |
| Organism | Homo sapiens |
| Length | 581 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (214)
Diseases linked to this target (Open Targets).
- psoriasis · score 0.32
- ulcerative colitis · score 0.31
- Crohn's disease · score 0.31
- ankylosing spondylitis · score 0.30
- sclerosing cholangitis · score 0.30
- amyotrophic lateral sclerosis · score 0.30
- gut microbiome measurement · score 0.29
- cortical surface area measurement · score 0.26
- systemic lupus erythematosus · score 0.14
- cutaneous melanoma · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2E8-F1 | alphafold | PREDICTED | 76.47 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2E8.
Amino-acid sequence (581 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC9A8?
The strongest Open Targets associations for SLC9A8 are psoriasis, ulcerative colitis, Crohn's disease, ankylosing spondylitis and sclerosing cholangitis.
How long is the SLC9A8 protein?
The Homo sapiens SLC9A8 protein (UniProt Q9Y2E8) is 581 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2E8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2E8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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