Myelin regulatory factor (MYRF)
Homo sapiens — UniProt Q9Y2G1
Data last refreshed: (UniProt release unknown)
Key facts
Myelin regulatory factor (MYRF) is a protein from Homo sapiens identified by UniProt accession Q9Y2G1, 1151 residues long. MolForge cross-references it against 0 known binders and 377 disease associations.
- UniProt accession: Q9Y2G1; gene symbol MYRF.
- Organism: Homo sapiens.
- Length: 1151 amino acids.
- Top disease associations (Open Targets): Cardiac-urogenital syndrome, encephalitis/encephalopathy, mild, with reversible myelin vacuolization and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Myelin regulatory factor |
|---|---|
| UniProt accession | Q9Y2G1 |
| Gene | MYRF |
| Organism | Homo sapiens |
| Length | 1151 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (377)
Diseases linked to this target (Open Targets).
- Cardiac-urogenital syndrome · score 0.71
- encephalitis/encephalopathy, mild, with reversible myelin vacuolization · score 0.59
- genetic disorder · score 0.49
- congenital heart disease · score 0.41
- Abnormal heart morphology · score 0.40
- disease of genitourinary system · score 0.40
- congenital diaphragmatic hernia · score 0.39
- hyperopia · score 0.38
- nanophthalmia · score 0.33
- disorder of sexual differentiation · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2G1-F1 | alphafold | PREDICTED | 60.43 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2G1.
Amino-acid sequence (1151 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MYRF?
The strongest Open Targets associations for MYRF are Cardiac-urogenital syndrome, encephalitis/encephalopathy, mild, with reversible myelin vacuolization, genetic disorder, congenital heart disease and Abnormal heart morphology.
How long is the MYRF protein?
The Homo sapiens MYRF protein (UniProt Q9Y2G1) is 1151 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2G1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2G1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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